"At least one person was taken to hospital, but the exact number of injured and the condition of the wounded is not yet known," spokesperson for the local Groningen crisis team, Cyriel Hamstra said.
Only about 20 people had been on the train at the time of the crash, he added.
The tanker truck was leaving a farm in the rural area of Winsum and "was probably driving over an unguarded railway crossing when it was hit by an oncoming train," Groningen police said on their Twitter account.
The driver of the truck had escaped unhurt, but dozens of rescue workers had been rushed to the scene, the police added.
De vrachtwagenchauffeur is overgebracht naar een politiebureau. Hij zal daar, na tussenkomst van een advocaat, worden gehoord als verdachte
— Politie Groningen (@POL_Groningen) November 18, 2016
Ambulances and a helicopter were already at the site of the crash which happened around midday (11:00 GMT).
The Landhi train tragedy
"Most of the injured are only slightly hurt," Groningen police spokesman Ernest Zinsmeyer told the NOS public broadcaster.
Television images from the NOS public broadcaster showed the first few carriages of the train had derailed, and it was partly tipped onto its side in a field.
"Er vlogen stukken glas, wand en mensen door de trein heen", vertelt een passagier uit de trein die ontspoorde: https://t.co/5iy52ERbCY
— NOS (@NOS) November 18, 2016
"There is a large presence" of rescue workers "to help the wounded", Hamstra said.
Rescuers could also be seen carrying stretchers to the derailed train. But police said other people had already been treated for their injuries on the scene.
Train links to the region had been stopped for the time being, and all the passengers were evacuated.
The crash happened at a place where the railway line passes through several fields following the path of a canal, according to the television images.
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