According to sources, police and Rangers took the ex-Pakistan Peoples Party (PPP) leader into custody from his house in the city's Rizvia Society.
Sectarian strife: Six ASWJ men shot dead
The development comes hours after five members of Ahle Sunnat Wal Jamaat (ASWJ), including two prayer leaders, were shot and killed in three separate shooting incidents in Karachi on Friday.
Once a close confidant of former President Asif Ali Zardari, Abidi resigned from Senate and as PPP's Karachi president in 2012 and 2013 respectively, after developing differences with the party leadership.
Sources said he has been shifted to an undisclosed location for questioning.
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