PHOTO: REUTERS
https://twitter.com/bieberfeverUS/status/742202368129957888
The pontiff condemned the killings as "homicidal folly and senseless hatred" while Obama described them as "an act of terror and an act of hate".
Deadly rampage: Orlando hit by worst shooting in US history
According to a tweet from the British royal family's official account, the queen was "shocked" by the attack, adding that the monarch and her husband's "thoughts & prayers are with all those who have been affected".
The Queen: "Prince Philip & I have been shocked by the events in Orlando. Our thoughts & prayers are with all those who have been affected"
— The Royal Family (@RoyalFamily) June 12, 2016
The attack in which a gunman opened fire at a packed nightclub in Orlando, Florida, is the worst mass shooting in US history.
Leaders from countries shaken by recent 'militant' attacks, including France and Belgium, were among the first to express solidarity with the US.
Afghan President Ashraf Ghani sent his condolences to the families of the victims as authorities identified the alleged gunman as 29-year-old Omar Mateen, a US citizen of Afghan descent.
"I unequivocally condemn the horrific attack in Orlando, Florida, USA. Nothing can justify killing of civilians," Ghani tweeted.
Severely condemn the heinous & unforgivable crime in Orlando. It was a coward act of terror. Praying for all those affected by this tragedy.
— Ashraf Ghani (@ashrafghani) June 12, 2016
Reacting to the latest in a litany of mass gun killings in the US, Obama said the FBI was "appropriately investigating this as an act of terrorism".
"Although it's still early in the investigation, we know enough to say that this was an act of terror and an act of hate," he said, later ordering flags at half-staff as an act of mourning.
In a statement from the Holy See, the pope lamented the tragic loss of life.
Police reveal names of Orlando club shooting victims
The attack had "caused in Pope Francis, and in all of us, the deepest feelings of horror and condemnation... before this new manifestation of homicidal folly and senseless hatred", said the statement.
"We all hope that ways may be found, as soon as possible, to effectively identify and contrast the causes of such terrible and absurd violence," it added.
In France, which remains on edge after Islamic State group militants killed 130 people in Paris in November 2015, President Francois Hollande reacted "with horror".
The president "expresses the full support of France and the French people to the US authorities and the American people during this ordeal", a statement from the Elysee Palace said.
Prime Minister Manuel Valls also expressed his "compassion" and "solidarity" with the American people.
"By striking the gay community, this terrible Orlando attack reaches us all," he wrote in French on Twitter.
https://twitter.com/manuelvalls/status/742005093747294208
Belgium's Prime Minister Charles Michel tweeted his condolences over the attack, which comes two-and-and-half months after dual strikes by militants on Brussels airport and metro that killed 32 people.
"Deeply saddened by the loss of so many innocent lives in Orlando shooting. We join families in their grief," he said.
Deeply saddened by the loss of so many innocent lives in #OrlandoShooting We join families in their grief.
— Charles Michel (@CharlesMichel) June 12, 2016
In Britain, Prime Minister David Cameron said on Twitter he was "horrified" by the shooting. "My thoughts are with the victims and their families," he said
I'm horrified by reports of the overnight shooting in Orlando. My thoughts are with the victims and their families.
— David Cameron (@David_Cameron) June 12, 2016
Israeli Prime Minister Benjamin Netanyahu, whose country saw four people shot dead by two Palestinian gunmen on Wednesday, also described the killings as "horrific".
Orlando shooter underwent company screening in 2013 with 'no findings'
"On behalf of the people and government of Israel I extend our deepest condolences to the American people following last night's horrific attack on the LGBT community in Orlando," he said in a statement issued in English.
"Israel stands shoulder to shoulder with the United States at this moment of tragic loss," Netanyahu added.
Russian President Vladimir Putin, meanwhile in a Kremlin statement, called the killings "a barbaric crime".
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