The England international, 28, had last week equalled the record of scoring in 10 successive matches held, ironically, by former United striker Ruud van Nistelrooy.
Leicester hot-shot Vardy a "great" striker: van Gaal
He claimed the record outright in the 24th minute at the King Power Stadium by racing onto a through ball from Christian Fuchs and drilling a low, right-foot shot past David de Gea to put Leicester 1-0 up.
It was Vardy's 14th goal of the league campaign, which makes him the top scorer in the English top flight.
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