Around 10,000 troops are participating in Jordan's fifth "Eager Lion" annual war games, which will last for two weeks.
The aerial, ground and naval exercises come as a US-led coalition battles the Islamic State (IS) group in neighbouring Iraq and Syria.
Several other Arab states have joined a Saudi-led coalition carrying out air strikes on rebels in Yemen.
Read: Jordanian warplanes strike back at Islamic State after pilot's murder
Even so, "Eager Lion has nothing to do with what is currently happening in the region," US major general Rick Mattson told reporters in Amman.
"The more we work together the stronger we are."
Soldiers simulate a chemical weapons attack during the Eager Lion drills on June 2, 2014 in Zarqa, 30 km east of Amman. PHOTO AFP
As well as troops from the US and Jordan, military contingents from several nearby Arab states and troops from France, Italy and Pakistan will take part in drills in the Jordanian desert.
Read: Jordan executes two militants in 'earth-shattering' response to pilot murder
The exercises will focus on challenges such as "combating terrorism" and border security, said Jordanian Brigadier General Fhad al-Damin.
Jordan has intensified its air raids against IS since the jihadists burned alive one of its pilots who crashed in Syria earlier this year, but there are fears its participation in US-led strikes could drag the kingdom into nearby conflicts.
COMMENTS (5)
Comments are moderated and generally will be posted if they are on-topic and not abusive.
For more information, please see our Comments FAQ