The Britain-based Syrian Observatory for Human Rights said the 18 militants, reportedly including one of Chinese nationality, were killed in fighting near the town of Ain al Arab, known to the Kurds as Kobane.
The Observatory said Friday that Islamic State militants had seized 60 Kurdish villages near the Turkish border in a lightning two-day campaign as they close in on Ain al Arab.
The town in Aleppo province is Syria's third largest Kurdish town, and would give IS control of a long stretch of the country's northern border with Turkey.
The fighting in the area has prompted an exodus of residents, many of whom have sought to cross into Turkey, which opened its border on Friday.
The Observatory said the fighting was continuing on Saturday and reported "heavy clashes" in the area around Ain al Arab.
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@wiserneighbour: The problem now is not Islam- its high technology in the wrong hands. Recall Ojri camp and stinger rain. It will all stop as long as all the technology can be traced and destroyed.
finish them all!