Four masked gunmen on two motorbikes opened fire at the vehicles, forcing them to stop and then doused them in petrol to set them on fire in Balochistan.
"Five Nato trucks were carrying Nato equipment back. Gunmen first fired on the first vehicle and then sprinkled petrol on all of them," Iftikhar Bugti, a senior government official told AFP by telephone.
The incident happened in Bolan district, around 120 kilometres (75 miles) southeast of Quetta, the provincial capital.
"All five trucks have been almost completely destroyed," Bugti said. One driver was slightly injured in the attack, he added.
Syed Waheed Shah, another government official in Bolan, confirmed the attack.
Military officials said Sunday it would cost the United States $5-6 billion to remove military hardware and vehicles from Afghanistan, where Nato is ending its combat mission by the end of next year.
Brigadier General Steven Shapiro described it as "one of the most challenging military transportation operations in history in terms of scale and complexity".
Most of the hardware will be flown out of land-locked Afghanistan or taken by road to Pakistan's port of Karachi, despite complications with the route.
Pakistan in July 2012 temporarily stopped Nato traffic after gunmen attacked Nato trucks, killing a driver, in the northwestern border town of Jamrud.
Islamabad also imposed a seven-month blockade on overland Nato traffic after US air strikes killed 24 Pakistani soldiers in November 2011.
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