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Sources said that a suspected suicide bomber had exploded his vehicle near the checkpost.
"Half of the check post building has been destroyed in the blast," said a security official in Peshawar, warning that the casualty figure could rise.
"It was a suicide attack. The bomber used a water tanker, he rammed it into the outer wall of the building," the official said.
Earlier in March, five officials of the Frontier Works Organisation (FWO) were injured when a roadside remote-controlled bomb planted by unidentified militants exploded in Ghulam Khan tehsil on Saturday.
An official of the security forces said an explosion occurred near a vehicle carrying the workers around 10:30am, injuring all five.
He explained the workers were constructing the Ghulam Khan Highway and were on their way to the site.
Miranshah is a hotbed of militant activity. US drones have also repeatedly targetted militants in the area.
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