"If there is a rabid dog running around your neighborhood, you're probably not going to assume something good about that dog,” Carson, a front-runner in some opinion polls, said Thursday at a campaign event in Mobile, Alabama.
Republican candidate Carson says Muslims unfit to be US president
"By the same token, we have to have in place screening mechanisms that allow us to determine who the mad dogs are, quite frankly," the retired neurosurgeon said, criticizing President Barack Obama's plan to admit 10,000 Syrian refugees within a year.
Obama administration officials have emphasized the refugee vetting process, which can take as long as two years.
But Republican presidential candidates and dozens of Republican governors have come out strongly against the refugee plan this week following the deadly Islamic State attacks in Paris on Friday.
US states shun Syria refugees in wake of Paris attacks
On Thursday, the US House of Representatives, defying a veto threat by Obama, overwhelmingly passed Republican-backed legislation to intensify security screenings of Syrian refugees and suspend the program to admit 10,000.
Ibrahim Hooper, spokesman for the Washington-based Council on American-Islamic relations, denounced Carson's comments as "unconscionable," saying they point to Carson's "complete disregard" for American Muslims.
“It really is unconscionable that he would stoop to such levels in smearing people who are fleeing violence and oppression, seeking a better life. Something he, himself, would do if put in the same circumstances,” he said.
Trump considers getting 'rid of' Muslims when president
Carson said, "Who are the people who want to come in here and hurt us and want to destroy us? ... It is foolish for us to accept people if we cannot have the appropriate type of screening."
Carson has called for Congress to cut off funding to programs used to bring refugees into the country.
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