PHOTO: AFP
Pakistan, playing in their adopted home of the UAE where they have never lost a series, overcame the early loss of captain Misbah-ul-Haq after resuming on 222 for three.
Asad Shafiq (79) and Younus Khan (118) put on a partnership of 113 before the latter was dismissed via a sprawling Moeen Ali catch off Adil Rashid.
The highest total England have ever chased down successfully in a fourth innings is 332, against Australia in 1928-29. Abu Dhabi's first test was drawn.
Younis Khan becomes first Pakistani to score 9,000 Test runs
Sharjah will host the final game in the series from Nov. 1.
Younis Khan completes 31st century
Younis Khan completed his 31st century as Pakistan amassed a formidable lead on the fourth day of the second Test against England on Sunday.
Younis was unbeaten on 112 and Asad Shafiq 47 not out as Pakistan reached 311-4 at lunch, extending their lead to 447 at Dubai stadium.
Younis punched paceman Stuart Broad to the point boundary for his 11th four to reach three figures off 193 balls, his third hundred against England.
Raring Wahab Riaz happy to lead Pakistan attack
He has so far hit 12 boundaries during his 203-ball stay and added 87 in an unbroken fifth-wicket stand with Shafiq.
Pakistan, resuming on 222-3, looked for quick runs to set England a target and secure a 1-0 lead in the three-match series. The first Test in Abu Dhabi ended in a draw.
Misbah had scored a brilliant 102 in Pakistan's first innings of 378, but failed to add to his overnight 87.
Younis becomes Pakistan's highest run-scorer in Test cricket
He played an uppish shot to a slower delivery from fast bowler James Anderson which landed in the safe hands of Alastair Cook at mid-off.
Misbah hit eight boundaries and five sixes in his enterprising 147-ball innings.
England's bowlers failed to make an impact on the fourth-day pitch, with leg-spinner Adil Rashid costing 90 runs in his 22 wicketless overs.
Anderson with 2-22 and Mark Wood 2-29 were the most successful bowlers.
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