Pique has been targeted by sections of the Spanish support since he mocked Real Madrid during Barcelona's treble-winning celebrations at the end of last season.
Despite Spain coach Vicente del Bosque and his teammates' pleas for the unjust treatment to stop, the former Manchester United man was roundly whistled at the start of the match before some began to applaud him as the match developed.
Read: Euro 2016 qualifiers: Spain look to seal place amid question marks
"The tendency is changing. The whistles are heard more loudly than the applause but it is getting better," he said.
"In no moment will they find that I have said something negative about this national team or this country."
Pique, 28, is a huge personality in Spain as he has two sons with Colombian pop superstar Shakira and has campaigned in favour of a referendum to decide on Catalan independence.
However, he has previously stated he doesn't believe the Catalan issue is a reason for his treatment by the Spanish support as a host of other Catalan players in the squad have not been treated the same way.
"This is my home and my family. I have been coming here since the first day I was called-up and I have always been received warmly and treated well.
"They can't doubt me. The national team is part of me. I hope that this passes and they speak about football."
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