Last week, Australia agreed to expand into Syria the air strikes it has been undertaking in Iraq against IS, also known as Daesh, in response to a formal request from Washington.
Read: French air strikes on Islamic State in Syria 'in coming weeks': defence minister
"I can advise that two days ago the air task group completed its first strike against a Daesh target in Eastern Syria, destroying an armoured personnel carrier," Andrews told reporters in Canberra.
Andrews said the expansion of operations into Syria was a logical extension of Australia's commitment in the Middle East and was needed to protect the security of Iraq.
"(Daesh) controls a large amount of territory in eastern Syria that serves as a source of recruitment and oil revenues," Andrews said in a subsequent statement.
"From Syria, Daesh has been able to operate its training bases, conduct planning and preparation for attacks, and move fighters and equipment into, and out of, Iraq."
Read: Australia considers joining US-led Syria air campaign against Islamic State
Australia agreed a year ago to join the US-led international force battling IS in Iraq, committing a squadron of Super Hornet fighter jets, as well as support aircraft and a 600-strong group of airforce personnel and special forces soldiers.
COMMENTS
Comments are moderated and generally will be posted if they are on-topic and not abusive.
For more information, please see our Comments FAQ