England are seeking a win which would put them top of Group E but must do without Carrick, an unused substitute in Saturday's 6-0 away rout of minnow San Marino.
.@ManUtd midfielder @carras16 has withdrawn from the #3Lions squad due to injury and will return to his club. pic.twitter.com/iHdWQ9eXqE
— England (@England) September 7, 2015
However, the exact nature of the 34-year-old's injury was not disclosed.
The 33-times capped Carrick has not played for England since March's draw in Italy and, as a result, has missed the last three matches.
United play bitter rivals Liverpool in the Premier League on Saturday.
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