Rice, who had been suffering from a brain tumour and lung cancer, acknowledged in a recent interview that he was "in the departure lounge" but was determined to fight until the end.
He underwent robotic radiation treatment for the brain tumour in Indian city Bangalore and said in March that he believed the doctors there had saved him from death after he had been told he couldn't be treated in South Africa.
But he was admitted to a South African hospital two days ago, suffering from severe stomach pains, and a Cricket South Africa spokesman confirmed that Rice died early Tuesday.
Throughout a 24-year first-class career, Rice was renowned as a tough competitor.
He was selected for the Transvaal provincial team at the age of 20 and his potential as a fast bowling all-rounder was recognised two years later when he was selected for South Africa's scheduled 1971-72 tour of Australia.
The tour did not take place because of opposition to the South African government's apartheid policy and it was another 20 years before the country returned to official international cricket -- with Rice, then 42, captaining a team which played three one-day internationals (ODIs) in India.
But he was controversially not included in South Africa's team for the 1992 World Cup in Australia and New Zealand, with the selectors believing younger, more athletic players were needed for the big fields of Australia.
Ironically, it was because of Rice's athleticism and potential on those same big fields that he had been picked as a promising youngster for the cancelled 1971-72 tour.
Denied official international cricket, Rice's exploits were limited to South African domestic cricket, the English county championship and Kerry Packer's World Series Cricket -- and 18 unofficial Tests for South Africa against 'rebel' touring teams between 1982 and 1987.
Rice's career coincided with an era of notable all-rounders, including Ian Botham, Imran Khan, Kapil Dev, Richard Hadlee and fellow-South African Mike Procter.
Former South African captain Ali Bacher said: "I have no doubt that given the opportunity to play regular Test cricket, Clive Rice would have been right up there with the best all-rounders in Test history."
He was captain of the Transvaal 'mean machine' which dominated South Africa's domestic competitions during the 1980s.
It was a team packed with players of international standard, including South Africa's Cricketer of the Century Graeme Pollock, and other stars such as Jimmy Cook, Vintcent van der Bijl and West Indians Alvin Kallicharran and Sylvester Clarke.
Rice was uncompromising, insisting on his team maintaining their highest standards against all opponents.
"Don't ever let them think they might be able to beat you because if they do it once, they'll think they can do it again," he once said.
He was appointed captain of English county Nottinghamshire in 1978 but was sacked after joining World Series Cricket. Rice went to court to force the county to retain him on the staff and a season and a half later he regained the captaincy.
Forming a match-winning partnership with New Zealander Hadlee, he led Nottinghamshire to victory in the county championship in 1981 -- their first title in 52 years.
In naming Rice as one of their 1981 Cricketers of the Year, the Wisden Almanack likened the combination of Rice and Hadlee to the great Nottinghamshire pair of Harold Larwood and Bill Voce.
In 482 first-class matches he scored 26,331 runs at an average of 40.95 and took 930 wickets at an average of 22.49.
COMMENTS
Comments are moderated and generally will be posted if they are on-topic and not abusive.
For more information, please see our Comments FAQ