Simon, who developed "The Simpsons" in the late 1980s with Matt Groening and James L. Brooks, died of colorectal cancer on Sunday at his home in Los Angeles, Variety reported.
"A great man; I owe him everything," tweeted "The Simpsons" showrunner Al Jean, adding that his passing was "an enormous loss."
.@thesimpsons #everysimpsonsever Just heard terrible news of death of @simonsam. A great man; I owe him everything.
— Al Jean (@AlJean) March 9, 2015
.@thesimpsons #everysimpsonsever If you would like to honor Sam's memory, do something nice for the next animal you meet. An enormous loss.
— Al Jean (@AlJean) March 9, 2015
Simon left "The Simpsons" in 1993 but was still credited an an executive producer, and his leaving deal meant he could spend time and money on philanthropy, Variety said.
He estimated that his severance package earned him about $10 million a year, according to his IMDB industry database entry.
He shared seven Primetime Emmy awards for "The Simpsons" and two for his writing on "The Tracy Ullman Show," according to the industry journal.
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