The F-16 plane crashed shortly after taking off at the training center in Albacete, 262 kilometers south-east of the Spanish capital of Madrid.
"The plane, part of the Tactical Leadership Programme of NATO was carrying out a (training) exercise when during the take-off the plane lost power, crashing into the parking area for planes, crashing into various planes that were parked there," said the defense ministry in a statement.
The defense ministry said firefighters were working to put out a fire at the base and the area had been cordoned off.
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