Gunmen attacked three container trucks carrying Nato supplies en route to Afghanistan, killing two people, officials said.
Two other drivers were kidnapped by the attackers, Express News reported.
It was reported that there were more than 20 assailants who fired at the Nato trucks and later set the containers on fire.
"The three container trucks were on their way to Afghanistan when gunmen opened fire at them in Wazir Dhand area, killing two drivers and wounding two others," a senior local administration official, Ali Sher, told AFP.
He said two of the drivers were missing since the incident and it was not clear if they had escaped or if militants had kidnapped them.
Another local administration official also confirmed the incident and said the attackers had fled.
A doctor at the government-run agency headquarters hospital in Jamrud said two dead bodies and two injured were bought to the hospital.
"One of the injured was in critical condition and he has been shifted to Peshawar for further treatment" he said requesting not to be named as he is not authorised to talk to the media.
No group has claimed responsibility for the attack as of yet.
Today’s attack on Nato containers is not the first time the trucks have come under attack. Nato vehicles are frequently targeted by militants while carrying goods to and from Afghanistan.
Pakistan is a major transit supply route for the NATO mission in landlocked Afghanistan.
Previous attacks
On April 28, three separate attacks on Nato vehicles had left a man died and three others injured. The attacks had taken place on the Jamrud leg of the Pak-Afghan Highway.
On April 15, two people were killed and as many were severely injured in Jamrud when unidentified militants had attacked vehicles supplying goods to foreign troops stationed in Afghanistan. Ali Sher, an official of the Jamrud political administration, had said three attacks were carried out on Nato vehicles in different areas.
On March 4, two drivers of vehicles carrying Nato goods were killed and a cleaner injured when armed men opened fire at them in Sur Kamar, Jamrud.
In December last year, a group of armed men had attacked two containers carrying relief goods for Nato in the Dhadar area of Balochistan. No one was hurt in the attack.
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I vehemently condemn this act but security forces are at fault who did not provide cover to these trucks.Militants and hitman are destroying the vehicles of their own country for the pleasure of foreign masters. What is the sin of drivers' families who were waiting for them at home. Who will bear the expenses of education, health and marriages of their children.