
Smith, who made his return to cricket following a lengthy injury lay off with the recent tour against Pakistan in UAE, will be replaced by Henry Davids.
While Steyn and Kallis have been given time off on account of injuries ahead of a series against India, Smith has been allowed to leave following the death of his grandmother, Cricket South Africa said on Friday.
Paceman Steyn has a mild side strain while all-rounder Kallis has a badly sprained little finger.
Pakistan have already won the series against South Africa after success in the first two ODIs in Cape Town last Sunday and Port Elizabeth on Wednesday.
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