The bomb, detonated by remote control, exploded near a bus station in the remote town of Dera Allah Yar, around 170 miles (270 kilometres) southeast of Quetta, the provincial capital.
"At least six people have been killed and more than 15 injured. The bomb was planted on a motorcycle," police official Qamar Ul Hasan told AFP.
Hasan said the target of the attack was yet not clear.
"The bomb also badly damaged around five to six shops and destroyed some motorbikes and other vehicles," he said.
There was no immediate claim of responsibility.
Balochistan, which borders Afghanistan and Iran, is plagued by militancy, attacks on the Shia Muslim minority and a separatist Baloch insurgency.
The violence has raised concerns about security for Pakistan's general election, due to be held on May 11 and marking the country's first transition of power between two elected civilian governments.
Zulfiqar Ali, a second police official, confirmed the attack and warned that the death toll could rise further.
"All those killed were civilians," Ali told AFP.
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soon some ASWJ phobic psychoes will start fake propagenda against ASWJ,because these psychoes r in habit of blaming of ASWJ for evrything happening in pakistan,don knw what s wrong with them.
anyhow very sad news those involved in this incident should be hanged to death,enough is enough,we want peace,no more killing,plz plz plz stop killing each others