The strike occurred in Khar Qamar, a village in Datta Khel area, and was the fourth drone attack the past four days, a senior security official in the area told AFP.
"The US drone fired two missiles at the militants' vehicle, killing five rebels," he said. He said nationalities of the militants killed in the strike were not immediately known.
A senior local administration official also confirmed the strike and casualties.
More than 1,040 people have been killed in 121 drone strikes in Pakistan since August 2008, including a number of senior militants.
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