Amongst the killed were eight South Africans, the foreign ministry in Johannesburg said.
"Our mission in Islamabad in Pakistan, which is also accredited in Afghanistan, has informed us that eight South Africans were among the dead in the explosion which occurred in Kabul early this morning," foreign affairs spokesman Nelson Kgwete told AFP.
"They worked for a private aviation company," he added.
The group were all believed to be men, Kgwete said.
"Our mission in Islamabad is working on the identity of the men and contacting their next of kin."
The attack brings to more than 30 the number of people now killed in a violent backlash over a YouTube trailer for the film, "Innocence of Muslims", believed to have been produced by a small group of extremist Christians.
Security officials said nine foreigners were among those killed on a major highway leading to Kabul airport and close to a wedding hall when the bomber blew her station wagon up alongside a minivan carrying foreign workers.
An AFP photographer saw at least six bodies lying among the wreckage of a gutted minivan, and another vehicle destroyed by flames still burning in the middle of the highway, with debris flung all around.
Hezb-i-Islami, the second largest insurgent group after the Taliban who have been fighting US-led troops and the government for 10 years, claimed the attack.
"The bombing was carried out by a woman named Fatima. The bombing was in retaliation for the insult to our Prophet," spokesman Zubair Sidiqi told AFP in a telephone from an undisclosed location.
It is extremely rare for the faction to claim a suicide attack in Afghanistan. It is also rare for women to carry out suicide attacks.
Taliban fighters last week stormed a British-run airfield, killing two US Marines and destroying six US fighter jets also to avenge the film.
A week of furious protests outside US embassies and other American symbols in at least 20 countries have killed 19 other people, including the American ambassador to Libya and three other US diplomats in the North African country.
In Lebanon, the head of Shia Muslim movement Hezbollah, which is blacklisted in the United States as a terrorist organisation, made a rare public appearance to warn of "very dangerous" repercussions if the film is released in its entirety.
Tens of thousands of demonstrators poured into the streets of southern Beirut to denounce the film at the request of Nasrallah, who has called for a week of protests over the film, describing it as the "worst attack ever on Islam".
"The US must understand that releasing the entire film will have dangerous, very dangerous, repercussions around the world," he told the rally.
The filmmaker Nakoula Basseley Nakoula, a 55-year-old Egyptian Copt and fraudster who was sentenced to 21 months in prison in the US in June 2010, has not been seen since Saturday when he was questioned by his US parole officer.
The risks now facing those involved in the production of the film, were underlined when a Salafist cleric in Egypt called Monday for the deaths of all those involved in its making.
Before dawn on Monday, officers from the Los Angeles County sheriff's department escorted four members of Nakoula's family to join him in hiding.
"I issue a fatwa and call on the Muslim youth in America and Europe to do this duty, which is to kill the director, the producer and the actors and everyone who helped and promoted the film," said the Egyptian cleric, Ahmad Fouad Ashoush.
In Pakistan, two protesters died after demonstrating against the film in the northwest, close to the Afghan border, and outside the US consulate in Karachi.
The US embassy in the capital Islamabad closed on Monday because of the risk of demonstrations and diplomats have been banned from all but essential travel.
Pakistan has also blocked access to YouTube, following the video-sharing website's failure to take down the anti-Islam film.
Similar measures have been taken in Afghanistan. Google, which owns YouTube, has also barred access to the film in Egypt, India, Indonesia, Libya and Malaysia.
There have been violent demonstrations this week in Kabul and Jakarta, spreading from deadly demonstrations on Friday that saw police battle to defend US missions from mobs in Egypt, Lebanon, Sudan, Tunisia and Yemen.
The United States has deployed counter-terror Marine units to Libya to protect its embassy in Tripoli and stationed two destroyers off the North African coast.
On September 11, its consulate in the eastern Libyan city of Benghazi came under sustained attack, killing four Americans, including ambassador Chris Stevens.
A Marine unit was also dispatched to protect the US embassy in Yemen, where police shot dead four protesters and wounded 34 others on Thursday as a mob breached its perimeter. There were more protests in Yemen on Monday.
The United States has evacuated all non-essential staff and family members from Sudan and Tunisia and warned US citizens against travel to the two countries.
COMMENTS (10)
Comments are moderated and generally will be posted if they are on-topic and not abusive.
For more information, please see our Comments FAQ
@bill ivey: Dear Bill, We are all wishing the US would just do what you suggested. Quickly.
IM SICK OF SEEING SO MANY OF OUR BRAVE SOLDIERS AND REPRESENTATIVES COMMING HOME IN BODYBAGS FOR NO REASON WHATSOEVER! perhaps we should leave those countries alone,quit sending money we need here and produce our own energy(we have enough oil here). so much hatred from people i dont know or even care about for that matter! (especially for whoever made some silly movie)! truly a jim jones type of mentality! if i had the power for one day i would bring it home (quit spending money with those that hate and want to kill us all) of whatever so called religion we might be! oh yes next time they need our help tell them to call 911. I CERTAINLY HAVE NOT FORGOT AS IM SURE WE ALL REMEMBER THAT NUMBER
Point which innocent Muslims are not understanding that by such acts the enemies of Islam provoke the sentiments of Muslims and force them to indulge in to a rash and aggressive reaction. In all such activities including this recent one these enemies of Islam have been very successful. The aggressive reaction shown by Muslims is then taken to further spread the anti Islamic propaganda. For such occasions,teachings of prophet of Islam (pbuh) are entirely different. Sensible, rationale and logical approach is to curb such acts/propaganda by highlighting the noble aspects of Seerat of Prophet of Islam (pbuh). Protest letters/faxes/ emails to US authorities and to other heads of Christian countries/media houses is another wise move which can be undertaken. Resort to violent protests and atrocities against innocent people is a reaction which at least real teachings of Islam can never justify. Hopefully so called Muslim Leaders pledging revenge and promoting violence will pay heed to this aspect.
I fail to see exactly how killing innocent people who have absolutely NOTHING to do with the film equates revenge. It's just plain murder.
That being said, has anyone actually watched the film in ENGLISH?
1. It's extremely low budget and cheesy. I have friends who have made extremely low budget horror flicks at home that look better than this thing. 2. If you watch it in English, it is 100% OBVIOUS THAT ANY REFERENCES TO ISLAM, MUSLIMS, MUHAMMAD, etc. has been dubbed in after the fact.The actors say they were duped and that the original film was supposed to be a "historical desert drama". When I first read that, I was like, hhhmmmmm, yeah, riiiight. But, I finally watched the trailer this morning, and I admit, it is totally obvious.
In any of the parts of the film that the words Muslim, Islam, Muhammad, etc. are mentioned, the actors mouths do not move with the words, and you can clearly hear that those words have been dubbed in a voice that does not even come close to matching the actor's voice who is supposedly talking, and that the actors are, in reality, saying something totally different.
I feel really bad for the actors, they definitely were duped by this guy.
An Egyptian Coptic (criminal past) makes the movie in America. In Kabul a suicide bomber retaliates killing 8 South Africans. I cannot see if there is a connection? Why is there no condemnation of this act of violence. By remaining silent, one provides a tacit approvement of this act!!!!
Great what a revenge! No wonder religion is opium of masses. People do get high on it. In the meantime the maker is raking in the mullah ( the greenback variety).
At loss of any logical words to express myself...
The movie maker certainly achieved what he wanted; not because of his misguided efforts, but ignorance of others. sad, just sad.
so she blew up 12 other muslims to take revenge for film made in a foreign country, interesting
It is sad that when a lunatic creates a film, the blood of innocents is shed!!! What is this world coming to.