The strike call was given by the Baloch Republican Party and Jamhoori Watan Party.
Balochistan National Front, Balochistan National Party and Baloch Student Organisation are also participating in the strike.
All major shopping centres in Quetta are closed, with contingents of police, Balochistan Constabulary, Frontier Core and Anti Terrorist Force deployed throughout the city.
A complete shutter-down strike is also being observed in other areas of the province such as Noshki, Dalbadin, Mastung, Qalat, Pisni and Khuzdar.
Talal Bugti, president of the Jamhoori Watan Party and son of the late Baloch leader Nawab Akbar Bugti, had earlier filed a petition against former president Pervez Musharraf in Akbar Bugti's murder case.
The concerned authorities were not registering an FIR against Bugti’s murder till the Balochistan High Court ordered them to do so in October 2009.
Talal had also pleaded that Interpol should be activated to bring Musharraf back to Pakistan and face the law.
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