The operation, involving around 18,000 police officers, discovered fake or adulterated drugs purporting to deal with illnesses ranging from diabetes to high blood pressure and rabies, the ministry said in a statement on its website (www.mps.gov.cn).
The suspects went so far as to advertise their drugs online, in newspapers and on television, and the drugs caused problems ranging from liver and kidney damage to heart failure, it added.
"The criminals' methods were despicable and have caused people to boil with rage," the ministry said.
The government has repeatedly promised to tighten regulatory systems after safety scandals involving fish, drugs, toys, toothpaste, children's clothes, tyres, drugs and milk fortified with melamine, used in the manufacture of tabletops.
But little has been done apart from a few, highly publicised arrests. Tackling the issue has not been helped by China's confused and still developing regulatory environment, corruption and the high profits counterfeiters can rake in.
Earlier this year, Chinese consumers recoiled at stories of drug capsules tainted with chromium, long-term exposure to which can cause serious organ damage.
While it hailed the success of the latest raids, the ministry warned it was too soon to be able to rest on their laurels.
"The crime of making fake drugs is still far from eradicated, and criminals are coming up with new schemes, becoming craftier and better able to deceive," it said.
The ministry called on consumers to only use above board pharmacies and hospitals and not "easily believe advertisements".
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