Rescue teams reached the scene and shifted the injured, who were in critical condition, and the deceased to a local hospital.
Witnesses said the assailants were on motorcycles and opened indiscriminate firing on the men sitting at the hotel.
Police and Frontier Corps (FC) cordoned off the area.
It is suspected to be an incident of target killing which has become, along with bomb blasts, a common occurrence in the area.
Earlier, at least 14 people, including five children, were killed and over 48 sustained injures in a powerful remote-controlled blast outside a religious seminary near Bank Chowk on Saryab Link Road.
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