According to reports, a drone fired missiles at the house of a tribal leader, Jamal Wazir in Mir Ali Khushali area of North Waziristan.
The strike killed five people, while many are feared to have been injured.
US has been conducting regular drone strikes in Pakistan’s tribal areas targeting suspected militants believed to have been working with the Taliban, al Qaeda or associated organisations.
The drone strikes have become a major sticking point between Pakistan and the US especially since US forces raided a compound in the garrison town of Abbottabad deep in Pakistan and killed Osama bin Laden in May this year.
US has in recent days stepped up calls for the Pakistan army to move into North Waziristan and take action against the Haqqani network, a militant organisation which the US says orchestrates attacks against the US troops stationed in Afghanistan before escaping to safe havens in Pakistani tribal border areas of Waziristan.
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