
Two missiles fired by the drone hit the vehicle in Azam Warsak.
"At least four militants were killed in the strike," a local security official told AFP.
Another security official in the area confirmed Monday's strike and casualties, but said the identities of those killed were not immediately known.
The latest US drone attack was the first since July 12, when missiles hit a compound and a vehicle in the neighbouring North Waziristan tribal region, killing at least six militants.
The United States does not officially confirm Predator drone attacks, but its military and the CIA operating in Afghanistan are the only forces that deploy the armed, unmanned aircraft in the region.
More than 20 US drone strikes have been reported in Pakistan since May 2, when US elite forces killed al Qaeda chief Osama bin Laden.
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