The battles since Saturday on the edge of the rebel-dominated Idlib region are the most deadly since a Russia-brokered ceasefire went into effect in late August, the Syrian Observatory for Human rights said.
"Fighting raged at dawn Monday on several axes in the southeastern Idlib countryside," the Britain-based monitoring group said.
Fifty-one regime fighters had been killed over 48 hours, while 45 of their opponents including 31 militants had also lost their lives, the Observatory said.
At least 17 killed, 20 injured by car bomb in Turkey-controlled region of Syria
The Syrian government does not usually divulge casualty figures.
The Idlib region, home to around three million people including many displaced by Syria's eight-year civil war, is largely under the control of a group dominated by a former al Qaeda affiliate.
It is one of the last holdouts of opposition to forces backing Syrian President Bashar al-Assad.
The president has long repeated that his government would eventually reimpose its control over the northwestern region on the border with Turkey.
The late August ceasefire had brought about relative calm, months into a devastating Russia-backed regime offensive that killed around 1,000 civilians and ousted hundreds of thousands from their homes.
The war in Syria has killed more than 370,000 people and displaced millions since it erupted in 2011 with the brutal repression of anti-government protests.
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