Argentina, now unbeaten in six games since a disappointing Copa America, had the better of the early play but fell behind in the 34th minute when Edinson Cavani stabbed home from close range after a nice build-up by Luis Suarez and Lucas Torreira.
Messi, Tite exchange words as Argentina win 1-0
The crowd in Tel Aviv cheered Messi throughout and it was the forward who helped Argentina draw level in the 63rd. Messi's free kick from the left was nodded home by Sergio Aguero to put a more realistic sheen on the scoreline for the Argentines, who had been the more positive side throughout.
However, Suarez gave Uruguay the lead again in the 69th when he scored with a powerful 20-metre free kick that flew past goalkeeper Esteban Andrada into the top corner.
Messi says Ronaldo is the best striker he has ever seen
But the last word went to Messi who, three days after he missed from 12 yards against Brazil, made no mistake by coolly side-footing home from the spot to secure a deserved draw.
The fixture was the last international for both teams before they begin their 2022 World Cup qualifying campaign in March.
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