Williams suffered her fourth consecutive defeat in a Grand Slam final at the US Open earlier this month, as she again came agonisingly close to Australian Margaret Court's all-time record of 24 majors before falling in straight sets.
Williams has not won a set in any of the four Grand Slam finals she has reached since returning from maternity leave in September 2017.
At Flushing Meadows, she fell to a first-time Grand Slam finalist in Canadian teenager Bianca Andreescu.
Williams may not need statistics to prove her standing in the game but Mouratoglou is confident she has plenty of gas in the tank to continue her pursuit next season.
"I think time is working for her," Mouratoglou told Sky Sports. "I think she was much better at the US Open than she was at Wimbledon, and Wimbledon (was) better than Roland Garros. She is getting back in shape, and the more in shape she will be, the more dangerous she will be. I think she has started to play really good tennis."
Mouratoglou said Williams must play without the pressure of having to solidify her place in tennis history.
"This is the highest pressure anyone can have in life, and on the other side of the court she plays girls who have zero pressure because it is their first final," he said. "At some point, she will figure out how to deal with that."
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