The former Chelsea manager spent three trophyless seasons with Napoli and his decision to join Juventus has been viewed as a betrayal by his former club and supporters. PHOTO: AFP
The eight-time defending champions' first home game of the campaign pits them against last season's runners-up.
The 60-year-old has reportedly irritated club bosses by continuing to smoke despite his health issues.
Chain-smoking Sarri was photographed holding a packet of cigarettes while posing with fans outside his home earlier this week.
Despite his condition, Sarri has still conducted training sessions, and in recent days has come out on the pitch, according to reports in Italy.
The former Chelsea manager spent three trophyless seasons with Napoli and his decision to join Juventus has been viewed as a betrayal by his former club and supporters.
Juventus coach Sarri has pneumonia, club says
Sarri's continued absence could however provide a boost for Carlo Ancelotti's Napoli, who won their opening game 4-3 against Fiorentina.
Juventus posted an uninspiring 1-0 win over Parma last weekend with Cristiano Ronaldo having a goal controversially ruled offside by VAR.
Napoli's new Mexican signing Hirving Lozano could make his debut.
"I know Juve and I know how good they are," said former PSV Eindhoven winger Lozano. "But my new teammates are also strong.
"I also know how important it is when we play against them. I hope to get onto the pitch but that's up to the coach. I'm ready for any decision."
Juventus' close-season signing Aaron Ramsey could have to wait for his first start after skipping midweek training due to slight lower back pain.
"These direct clashes (between Juventus and Napoli) are difficult, but we often win them, we hope to continue like this on Saturday," said Juventus goalkeeper Wojciech Szczesny.
"It will be a hard-fought match."
Antonio Conte's new-look Inter Milan travel to Cagliari looking to continue their impressive start after 4-0 win over promoted Lecce.
Chilean forward Alexis Sanchez is set to complete his loan move to link up with former Manchester United teammate Romelu Lukaku.
Sardinians Cagliari were shocked in their opening match to promoted Brescia.
Brescia next travel to AC Milan, who crashed to a 1-0 loss at Udinese last time out.
Juventus gamble on Sarri delivering another style of Serie A title
At the Stadio Olimpico, Lazio and Roma go head-to-head in an early-season capital-city derby.
Roma were held 3-3 by Genoa last weekend with Lazio dispatching Sampdoria 3-0.
"The derby's importance is well-known for everyone here in Rome, and for us players as well," said Roma's Turkish forward Cengiz Under.
"We'll go out there and give everything we have to try and get the result we want.
"We have to get back in the Champions League."
Meanwhile, Bologna coach Sinisa Mihajlovic looks set to be on the bench again against SPAL Friday after being discharged from hospital after undergoing chemotherapy.
The 50-year-old had been hailed for his exceptional courage in attending his team's Serie A opener last weekend, in spite of his treatement for acute leukaemia.
New-look Juventus begin Serie A defence without ailing Sarri
Fixtures (all times GMT)
Friday
Bologna v Spal (1845)
Saturday
AC Milan v Brescia (1600), Juventus v Napoli (1845)
Sunday
Lazio v Roma (1600), Atalanta v Torino, Cagliari v Inter Milan, Genoa v Fiorentina, Lecce v Verona, Sassuolo v Sampdoria, Udinese v Parma (all 1845)
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