Reds' manager Jurgen Klopp on Monday revealed that both his star strikers — Roberto Firmino and Mohamed Salah — won't be available for the second leg.
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Salah was stretchered off after a head knock during the 3-2 win against Newcastle, while Firmino has a groin injury which rules him out of the match.
The news is not a good one for Liverpool who are currently fighting on two fronts for silverware.
Currently they are at the top of the English Premier League with 94 points with only game to plat in the season, against Wolves.
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Meanwhile, defending champions Manchester City are on 92 points, but have two games in hand with the latest match against Leicester City on late Monday night.
They play Brighton on the last day of the current season of the English Premier League.
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The loss of the two stars will see Klopp face a Barca side at Anfield, who are 3-0 up and also at full-strength after Luis Suarez and Lionel Messi were rested in the last La Liga match.
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