The Spaniard has won at Austin from pole every year since its arrival on the calendar in 2013.
He turns up for Sunday's race after a crushing 10-second success over arch-rival Valentino Rossi in Argentina.
That "perfect day" at Termas de Rio Hondo pushed Marquez up to the head of the championship standings with a four-point lead over Andrea Dovizioso before this third leg of the season.
Marquez, chasing a sixth world title in the elite division, is relishing the chance of another Texas triumph.
Austin "is one of my favourite tracks", he told his Honda team's website.
"These counter-clockwise circuits always seem to suit my style the best."
But he was wary of not allowing his accomplishments in Austin to lead to any complacency.
"Although we have achieved a lot of success here in the past, we will work as we always do from free practice one and remain focused. Every year when you go to a track there are new things to understand and adapt to."
Dovizioso has a best place runner-up finish to his name in 2015.
"Our aim is to once again be on the podium which would be almost like a win," said Ducati's Italian rider who was victorious in Qatar, adding the circuit "is not the best for us".
Marquez's new teammate, three-time former world champion Jorge Lorenzo, has had a tricky time of it since switching from Ducati.
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