France and Germany declined to send their top diplomats to the ministerial-level meeting. EU foreign policy chief Federica Mogherini also stayed away due to concerns it would become an anti-Iran vehicle. Britain, France and Germany, along with the rest of the EU, continue to support the nuclear deal as the best way to prevent Iran from developing atomic weapons.
At the close of the conference, Secretary of State Mike Pompeo and his Polish counterpart Jacek Czaputowicz both noted differences of opinion over policies toward Iran. But, they said all participants agreed on the threat posed by the country, which is celebrating the 40th anniversary of the Islamic Revolution this week.
"There was not a defender of Iran in the room," Pompeo said, adding that the US and Europe were still capable of working together on the issue.
Iran seeks European assurances as US oil sanctions loom
Czaputowicz said the US and Europe "share the same diagnosis of the situation," which is "the negative role played by Iran." But he also noted that the US and Europe differ on how to approach the matter.
In his earlier speech, Pence showed just how sharp that difference is.
He was harshly critical of Britain, France and Germany for unveiling a new financial mechanism last month that US officials believe is intended to keep the nuclear deal alive by evading American sanctions. Pence praised other nations for complying with US sanctions by reducing Iranian oil imports, but he said the Europeans fell short.
"Sadly, some of our leading European partners have not been nearly as cooperative," Pence said. "In fact, they have led the effort to create mechanisms to break up our sanctions."
He said the mechanism, a barter-type payment system that is designed to allow businesses to skirt direct financial transactions with Iran, is "an effort to break American sanctions against Iran's murderous regime."
"It's an ill-advised step that will only strengthen Iran, weaken the EU, and create still more distance between Europe and the United States," the vice president said.
Pence then called for Europe to abandon the nuclear agreement altogether, making explicit a demand that Trump administration officials had previously only hinted at.
"The time has come for our European partners to withdraw from the Iran nuclear deal and join with us as we bring the economic and diplomatic pressure necessary to give the Iranian people, the region and the world the peace security and freedom they deserve," he said.
EU hits Iran with sanctions after murder plots
Niels Annen, a German deputy foreign minister who participated in the conference, told reporters after Pence spoke that Europe has a common position on the need to preserve the nuclear deal, and he dismissed US concerns about the new financial mechanism. He said Germany believes both pressure and nuclear deal need to be maintained.
"We believe we need both," he said. "We need pressure on Iran ... but we also need cooperation on the basis of this international agreement and we will continue to pursue this together."
Germany, Britain and France have vigorously defended the new payment system as necessary to preserve the Iran accord, under which Tehran was granted billions of dollars in sanctions relief in exchange for curbs on its nuclear program.
They are also highly unlikely to withdraw from the agreement, a signature foreign policy achievement of the Obama administration. Their governments have repeatedly expressed support for it since Trump declared the US would pull out.
The UN's atomic watchdog and Trump's own intelligence chiefs have said Iran remains in compliance with the agreement despite the US withdrawal.
Pence, however, said Iran's adherence to the deal's terms is irrelevant. He said the accord was fatally flawed to begin with as it does not prevent Iran from obtaining the technology or material to eventually develop a nuclear weapon over time.
"Compliance is not the issue; the deal is the issue," he said, calling Iran the "single greatest threat" to security in the Middle East.
Iran was not invited to the Warsaw conference and called the event a "circus" aimed at "demonizing" the country.
Because of European reluctance to attend a conference focused only on Iran, Pompeo and other US officials had sought to broaden the scope to include other Middle East topics. The schedule included sessions on the Israeli-Palestinian conflict, Syria, Yemen, cybercrime and terrorism.
"No one country will dominate the discussion today, nor will any one issue dominate our talks," Pompeo said at the opening of the conference,
But Pence's comments, as well as earlier remarks by Pompeo, made clear the meeting was largely focused on isolating Iran.
Before the event opened, Pompeo met with Israeli Prime Minister Benjamin Netanyahu and said, "You can't achieve peace and stability in the Middle East without confronting Iran. It's just not possible."
Pence opened his keynote address by lauding the Trump administration's commitment to fighting "radical Islamic terrorism," a term he used in some form at least seven times.
He hailed gains made against the Islamic State group in Iraq and Syria, where the extremists are being ousted from their last remaining areas of control. Despite Trump's abrupt decision to withdraw American troops from Syria, Pence said the US would remain in the region to ensure the militant organization does not return.
"We will continue to hunt down the remnants of ISIS wherever and whenever they rear their ugly head," he said.
No matter what the conference yields on Syria, the future of the country was more likely to be determined at a Thursday meeting between Russian President Vladimir Putin and the presidents of Iran and Turkey
The three leaders were in the Russian Black Sea resort of Sochi to discuss a Syria peace settlement as expectations mount for an imminent and final defeat of IS ahead of the US pullout.
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