
Israel's military said its troops resorted to live fire, and an air strike, after explosive devices and rocks were thrown at them and to prevent breaches of the border fence from the Hamas-controlled enclave.
Gaza health officials said 290 people had been wounded, 90 of them by gunshots. They identified the dead as males, two of them aged 12 and 14.
Israeli troops kill Palestinian at Gaza border protest, ceasefire efforts continue
The boys' families could not immediately be reached for comment. At least 190 Palestinians have been killed since the Gaza protests began on March 30 to demand rights to lands lost to Israel in the 1948 war of its foundation, and the easing of an Israeli-Egyptian economic blockade.
Hamas said on Friday's protest also marked the 18th anniversary of the launch of the last Palestinian revolt against Israel.
A Gaza sniper has killed one Israeli soldier and incendiary devices flown over by Palestinians using kites and helium balloons have set off fires that destroyed tracts of forest and farmland in Israel.
Palestinian killed as Gaza protests against Israel enter fourth month
Israel accuses Hamas, against which it has fought three wars in the last decade, of having deliberately provoked violence in the protests, a charge Hamas denies.
More than 2 million people are packed into Gaza, whose economic plight is a focus of so-far fruitless US-led efforts to restart Israeli-Palestinian peace talks, stalled since 2014.
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