Here's a look at this year's session:
With so many world leaders in one place, security is ultra-tight. New York police are shutting down streets to traffic near UN headquarters in midtown Manhattan and warning New Yorkers to brace for gridlock. The annual gathering elicits complaints from New Yorkers having to deal with a steady stream of motorcades and detours to get to work.
Among leaders making UN debut: a new mother with baby in town
From Tuesday, 81 heads of state and 47 heads of government along with dozens of foreign ministers will take turns at the General Assembly podium. President Donald Trump will be the second speaker, right after Brazil's President Michel Temer. France's Emmanuel Macron and Iranian President Hassan Rouhani are also speaking on the first day. On the sidelines of the speeches, some 342 meetings are scheduled and hundreds of bilateral talks in a marathon that UN ambassadors have dubbed "diplomatic speed-dating."
Several leaders are making their debut on the world stage including from Africa: Zimbabwe's President Emmerson Mnangagwa, Ethiopian Prime Minister Abiy Ahmed, South African President Cyril Ramaphosa and Angolan President Joao Lourenco. Other newcomers include Cuban President Miguel Diaz-Canel, Italy's Prime Minister Giuseppe Conte, Chilean President Sebastian Pinera, Spanish Prime Minister Pedro Sanchez and Colombian President Ivan Duque Marquez.
World leaders at UN look for progress on North Korea, brace for Trump
The United Nations is getting a serious dose of star power on Monday, when K-pop sensation BTS - the world's most popular boy band - speaks at the launch of the "Generation Unlimited" UNICEF campaign. British-Lebanese international lawyer Amal Clooney will for the first time speak on the case of two Reuters journalists jailed in Myanmar and actress Anne Hathaway will address a UN event on gender equality.
UN chief Antonio Guterres is hosting a luncheon for world leaders on Tuesday that caters to a wide range of culinary tastes. Lunch starts off with a small plate of cured gravlax carpaccio, followed by pan-seared Wagyu beef filet with grilled asparagus. For desert: bittersweet chocolate mousse, chocolate dacquoise filled with raspberry coulis and chocolate rasberry.
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