Two police officers approached two sleeping men and asked them to move on.
One then pulled out a knife and refused to drop it when asked, Brussels police spokesperson Ilse Van de Keere said.
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The officers also used a baton and sprayed the man with gas. "The person continued to be threatening and injured the officer in the head," Van de Keere said.
The officer sustained a light cut. The other officer then fired on the man, hitting him in the chest and leg, police said. Police gave no details on the suspect's identity.
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