The explosion happened outside the Nangarhar provincial governor's office in the capital Jalalabad, his spokesperson Attaullah Khogyani told AFP.
Afghanistan extends Taliban ceasefire after suicide attack kills 25
It was also close to the Indian consulate.
Khogyani said 14 people had been killed and 45 wounded. An Afghan security source confirmed the suicide attack but gave a lower death toll of at least 10.
There was no immediate claim of responsibility for the blast.
Khogyani said a suicide bomber on foot had targeted Taliban, local elders and civilians as they left the governor's compound where they had attended a special event for the Eid holiday.
Taliban say ceasefire will not be extended, fighting to resume
On Saturday, a suicide attack on a gathering of Taliban, security forces and civilians in a district of the same eastern province of Nangarhar killed at least 36 people and wounded 65 others, provincial health director Najibullah Kamawal told AFP.
Eight killed as suicide bomber targets Afghan clerics in Kabul
The Islamic State group's Afghanistan franchise claimed responsibility for that attack.
COMMENTS
Comments are moderated and generally will be posted if they are on-topic and not abusive.
For more information, please see our Comments FAQ