There were 26 passengers and six crew, the ministry said.
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"The reason for the crash according to preliminary information could have been a technical fault," the ministry said, adding that the plane had not come under fire according to a report from the ground.
The transporter was around 500 metres from the runway, the statement said.
A commisssion will investigate the causes of the crash.
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The ministry was cited as saying that the plane crashed at Russia's Hmeymim air base in Latakia Province and that initial information suggested the crash may have been caused by a technical fault.
It was quoted as saying that 26 passengers and six crew members were on board.
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