Wolfsburg took the lead against the run of play on 15 minutes, Paul Verhaegh coolly slotting home a penalty after Ibrahima Konate's foul on Mario Gomez. Despite continuing to dominate, Leipzig could not break through before half-time.
The visitors burst out of the blocks after the break, and were rewarded on 52 minutes as Marcel Halstenberg squeezed the ball past Koen Casteels for the equaliser.
As Wolfsburg rallied late in the game, Divock Origi should have restored the lead for Wolfsburg in the 78th minute. The ball fell to the Liverpool loanee just metres in front of goal, but he somehow sent it soaring over the crossbar.
Leipzig's night went from bad to worse in injury time as Dayot Upamecano saw a second yellow card for a foul on Victor Osimhen.
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