Portugal international Sanches, who signed for the club on loan from Bayern Munich, came off 12 minutes from time in last Saturday's 2-1 loss to Leicester City with a thigh injury.
Dyer available for selection, confirms Clement
Sanches also missed the game against Huddersfield Town on October 14 after picking up a thigh strain while training with Portugal earlier this month but Clement said that the knock against Leicester was a fresh injury.
"It is not the same one that he had while he was at the national team earlier this month," Clement told the club's website. "But it will keep him out of this game and possibly at the weekend as well."
Swans will attack Hammers, vows Clement
The manager confirmed that striker Wilfried Bony, who has made only four league appearances for the club this season, is also out of the United game with a hamstring injury.
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