The late November visit comes as western Rakhine state is devoured by communal violence that has sent unprecedented numbers of Rohingya fleeing into neighbouring Bangladesh.
Myanmar's army is accused of using a crackdown on militants to expel its Muslim Rohingya population - a persecuted minority the Pope has previously called "brothers and sisters".
Rohingya in Pakistan fear for relatives in Myanmar
Any comments seen to support the Rohingya could provoke a strong reaction from hardline Buddhist clerics and a Buddhist-majority public aggrieved at global support for the Muslim group.
Myanmar has a small roughly half a million Catholic population, mainly in the remote north. The same goes for Muslim-majority Bangladesh - where the Pope will travel on to.
A spokesperson or the Catholic Church in Myanmar said it was unclear whether the Pope would address the Rakhine crisis during his November 27-30 trip.
"We don't know yet what will be his speech... but he is coming for the sake of the country and he will be talking about peace," Father Mariano Soe Naing, a spokesperson for the Catholic Bishop's Conference of Myanmar said.
"There won't be any interfaith meetings because of the lack of time," he said, although he will meet with the main Buddhist authority.
Some 200,000 people are expected to attend a mass led by Francis in Kyaikkasan Grounds, a stadium in Yangon, he added.
Myanmar and the Vatican only established full diplomatic relations in May, shortly after de facto leader Aung San Suu Kyi met Pope Francis during a European tour.
That visit was overshadowed by her country's treatment of the Rohingya, who are denied citizenship by the state and have previously been displaced in huge numbers by communal violence and army campaigns.
Only weeks before his meeting with Suu Kyi, Francis described the Muslim minority as "brothers and sisters" who were being tortured and killed for their faith.
He added they were "good and peaceful people who have suffered for years".
Any repetition of that stance will put Francis at odds with many inside Myanmar, where authorities have denied committing atrocities and tried to cast the Rohingya as the villains.
Buddhist nationalist hardliners have previously vowed to protest the papal visit because of his support for the Muslim group.
Myanmar army chief says Rohingya Muslims not native, refugee numbers exaggerated
This week Myanmar's government called for unity with a large inter-faith rally in Yangon, the first since the Rakhine crisis.
According to an itinerary released by the Vatican, Francis will travel to the capital Naypyidaw and the country's largest city Yangon before heading to Bangladesh - a country that had to absorb the more than 520,000 Rohingya who have fled the Myanmar army's campaign since August 25.
There will be no stops in Rakhine - the epicentre of the unrest - or meetings with Muslim clerics, according to the schedule.
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