Police said they were called just before 1900 GMT to the Stratford Centre, close to London's Olympic Stadium, following reports of a group of males spraying what was believed to be a noxious substance.
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London Ambulance Service tweeted that they had treated at least five patients after sending paramedics and a fleet of ambulances.
We have treated at least five people and taken three of them to hospital following the incident in #Stratford. We remain on scene. pic.twitter.com/MgF5jgHeYo
— London Ambulance Service (@Ldn_Ambulance) September 23, 2017
The injuries were believed to have been sustained in different locations, with one male arrested on suspicion of grievous bodily harm, police said.
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Witnesses told the Press Association that an argument had broken out shortly beforehand. Burger King employee Hossen, 28, said a local homeless man came into the fast food outlet "to wash acid off his face".
There were 431 acid attacks in London last year, 398 of which were carried out in Stratford's borough of Newham.
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