Spurs' hopes of winning last season's Premier League title were all but ended when they went down to a 1-0 defeat at the London Stadium in May.
But despite an early defeat by Chelsea at their temporary home ground of Wembley, Spurs are in fifth spot in the early table and Pochettino says they have moved on from last season's disappointment.
Spurs out to continue winning run at Wembley
"We were very frustrated and disappointed," said Pochettino. "We were fighting for the Premier League. It wasn't our best performance but now is a different season and different circumstance. We are so excited to play and try to win three points.
He added: “You know very well derbies are special games. It means more than only three points when you play Arsenal, West Ham and Chelsea. They will be very motivated. That is why it is not important what happened last week or before."
Tottenham will have left-back Ben Davies available again for selection after an ankle injury and have reported no fresh concerns.
Beating Dortmund ‘massive’ for confidence: Pochettino
"Harry is one of the best strikers in the world," he said. "Many people talk about him winning trophies for Harry to stay here with us. It is all very clear with Harry as people recognise his value. He is still one of the best players. But he loves Tottenham and wants to play here for a long time. I respect every single opinion. Tim has a right to speak about Tottenham and Harry."
West Ham manager Slaven Bilic is full of praise for Spurs, saying they have no Premier League peers when it comes to playing style.
"For me they are the team that plays the most attractive football and for me they are definitely one of the contenders to win the league," he said. "They have individual quality, they have pace and they are the team building up for three years now."
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