The strike hit a vehicle in Saeed district late Friday killing the driver and both passengers, the official said.
Washington considers Al-Qaeda's Yemen-based branch to be its most dangerous and has conducted a long-running drone war against its leaders.
Soldier, 3 assailants dead in Qaeda attack on Yemen army
Since President Donald Trump took office in January, the campaign has intensified.
Last month, US commandos conducted a ground raid on an Al-Qaeda headquarters compound in Marib province, further north, killing at least seven militants in a fight that left several US troops wounded.
Suspected al Qaeda militants attack Yemen army camp, 12 dead - military official
For more than two years, Yemen has been locked in a devastating civil war between the Saudi-backed government and Shia rebels who control the capital.
Al-Qaeda has taken advantage of the conflict to expand its presence in several areas of southern and eastern Yemen under the nominal control of the government and its allies in a Saudi-led military coalition.
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