The unlikely pair chats online in the video posted on Facebook, and urge people to break the stigma surrounding mental health.
"It's time that everyone speaks up and really feels very normal about mental health, it's the same as physical health," the Duke of Cambridge told Lady Gaga from Kensington Palace in London.
Prince Harry takes two-day course on mental health counselling
"It's so important to break open that fear and that taboo which is only going to lead to more problems down the line," he said.
In an open letter published last year on the website of her Born This Way Foundation, Lady Gaga revealed that she was suffering from Post Traumatic Stress Disorder.
"There is a lot of shame attached to mental illness, you feel like something's wrong with you," the singer told Prince William from her home in Hollywood. "We have to make the strongest, most relentless attempt we can to normalise mental health issues, so that people feel like they can come forward," she added.
The video - which had been watched over 500,000 times within hours of its release - is part of the Heads Together campaign, a mental health charity championed by William, his wife Kate and brother, Prince Harry.
Mental health care: Mind matters
It comes a day after Harry revealed that he spent years in "total chaos" as he struggled to deal with his emotions following the death of his mother, Princess Diana, when he was just 12. Prince William was 15 at the time.
He said he eventually sought help from mental health professionals at the age of 28, after encouragement from others, including "huge support" from his older brother.
Watch the video here:
Have something to add in the story? Share it in the comments below.
COMMENTS
Comments are moderated and generally will be posted if they are on-topic and not abusive.
For more information, please see our Comments FAQ