Interior Minister Suleyman Soylu said no external forces had been involved in the incident in the restive majority Kurdish city which happened during repair work on armoured vehicles at police headquarters. He said one person was seriously hurt while another was trapped under rubble.
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The blast, which could be heard in several areas across the city added to security jitters just days ahead of a key referendum expanding President Recep Tayyip Erdogan's powers. Grey smoke rose from the area as ambulances rushed to the scene, with medics saying at least five people were hurt.
"There was no intervention from outside. An explosion happened during repairs to vehicles," Soylu was quoted as saying by the private NTV television.
Turks will on Sunday vote on whether to approve constitutional changes giving Erdogan executive presidential powers, which critics say would drag the country into one-man rule.
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The southeast has been battered by renewed fighting between Kurdish rebels and Turkish security forces since a fragile truce collapsed in summer 2015. The outlawed Kurdistan Workers' Party (PKK) has been waging an insurgency against the Turkish state since 1984 during which over 40,000 people have been killed.
The group is designated by Ankara, the United States and the European Union as a terror group.
Diyarbakir city and its region has over the last year been repeatedly hit by PKK attacks targeting the security forces.
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