Two missiles hit a vehicle on the outskirts of the town of Mudiyah in Abyan province, killing all four people inside, the official said.
Over 50 dead in first US raid on Yemen under Trump
The raid comes two weeks after US President Donald Trump's administration reportedly gave the CIA new powers to conduct drone strikes against targets in the Middle East.
Since March 2, the US has launched dozens of strikes against Al-Qaeda in the Arabian Peninsula targets in Abyan and the neighbouring provinces of Shabwa and Baida.
Four al-Qaeda members killed in Yemen drone strikes
In the first three days of the strikes at least 22 suspected AQAP fighters were killed, security officials and tribal sources have said.
More than two years of civil war in Yemen between government forces and Shia rebels who control the capital have created a power vacuum which AQAP has exploited to consolidate its presence in the south and east.
Washington regards AQAP as the militant network's most dangerous arm and says that in recent months it has been plotting attacks on the West.
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