The Italians never looked like relinquishing their 2-0 lead from the first leg of the last 16 tie in Portugal three weeks ago, despite allowing the visitors plenty of possession in the first half.
Dybala sparks 10-point lead for Juventus
Porto's lingering hopes ended when Maximiliano Pereira stopped Juve striker Gonzalo Higuain's goalbound shot with his hands and was sent off, leaving Dybala to dispatch the penalty with aplomb three minutes before halftime.
Francisco Soares missed Porto's best chance when he got clean through early in the second period, but sent his shot wide of Gianluigi Buffon's goal.
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