Mayweather, who retired in September of 2015 after accumulating a perfect 49-0 record, told ESPN he would require a guaranteed $100 million to make the fight happen.
“I’m a businessman and it makes business sense,” said the 39-year-old American. “Bring him over to the boxing world, and I'll show him what it's like.”
McGregor challenges Mayweather again, demands $100 million for bout
Irishman McGregor, the reigning lightweight and former featherweight UFC champion, has been challenging Mayweather to a fight for months.
The biggest pay-per-view draw in mixed martial arts, McGregor is contracted to UFC and the organisation would have to approve any fight.
Mayweather, who won world titles in five weight divisions and took home earnings in excess of $800 million over his 19-year boxing career, said initial talks had taken place.
McGregor knocks out Alvarez to make UFC history
“We tried to make the Conor McGregor fight,” he said.
“They know what my number is. My number is a guaranteed $100 million. That was my number.
“We are willing to give him 15 million and then we can talk about splitting the percentage, the back end, on the pay-per-view,” he added.
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