Pakistan, who began the day on 114 for one, declared at lunch on 227 for two after Azhar Ali made 79 and Asad Shafiq was unbeaten on 58. That gave the bowlers five sessions to claim victory and an unassailable 2-0 lead in the series.
West Indies' hopes lie with Roston Chase (17 not out) and Jermaine Blackwood (41 not out), who put on an unbroken fifth-wicket stand of 47. The same batsmen were together at the start of the final day of the second Test against India in Jamaica in August, which West Indies went on to draw.
Pakistan build commanding 342-run lead over Windies
Repeating that feat against Pakistan's Yasir Shah will require great application on Tuesday. The leg-spinner claimed a wicket with only his third ball which Leon Johnson (9) dragged on to his stumps.
Yasir also had the dangerous Marlon Samuels caught and bowled for 23 after Darren Bravo (13) and Kraigg Brathwaite, leg-before to Mohammad Nawaz for a defiant 67, had attempted to provide the base for West Indies to chase down their 456-run victory target.
Pakistan all out for 452 against West Indies
The third Test will be played in Sharjah from October 30.
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